FORMULATION AND EVALUATION OF BIOADHESIVE PULSATILE DRUG DELIVERY SYSTEM OF AN ANTILIPIDEMIC DRUG
Snehal U. Shinde*, Pallavi M. Sangave, Kajal B. Chougule, Sachinkumar V. Patil Shitalkumar S. Patil and Dipak Bhingardeve
ABSTRACT
The main objective of this study is to formulate and evaluate of Bioadhesive pulsatile drug delivery system of an antilipidemic drug. In order to achieve an improved therapeutic efficacy. The present research work describes the combination of Bioadhesive pulsatile principles are very suitable for site and time specific. Gastroretentive drug delivery is an approach to prolong gastric residence time, thereby targeting site specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effects. several gastroretentive drug delivery approaches being designed and developed, including high density (sinking) systems that is retained in the bottom of the stomach,
low density (floating) systems that causes buoyancy in gastric fluid, mucoadhesive systems that causes bioadhesion to stomach mucosa, unfoldable, extendible, or swellable systems. The bioadhesive pulsatile tablet was prepared satisfactorily with no weight variation and hardness within official limit. In drug release study lag time up to 7 h. Thus bioadhesivepulsatile drug delivery system is best option for anhyperlipidemic patients.
Keywords: Bioadhesive, gastrointestinal tract, pulsatile, lag time, therapeutic efficacy.
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