Abstract

PHYTOCHEMICAL SCREENING AND IN VIVO ANTI-ULCER ACTIVITY OF METHONOLIC EXTRACT OF CRESSA CRETICA (LINN)

E. Nagarjuna Babu*, N. Anusha and A. Prameela Rani

ABSTRACT

An ulcer is defined as “disruption of the mucosal integrity of the stomach and/or duodenum leading to a local defect or excavation due to active inflammation”. Ulcers may range in size from several millimeters to several centimeters starting from small, painful sores in the mouth to bedsores and serious lesions of the stomach or intestine. Different types of ulcers are seen such as, Peptic ulcer, Duodenal Ulcer, Gastric ulcer, Esophageal ulcer, Bleeding ulcer, Refractory ulcer, Stress ulcer. Most of patients with peptic ulcers present with abdominal discomfort, pain, or nausea. Herbal medicines have a strong traditional or conceptual base and the potential to be useful as drugs in terms of safety and effectiveness leads for treating different diseases. Preclinical experiments are done to screen the anti ulcer activity in herbal drugs using various animal models. Cressa cretica (Linn) belonging to family Convolvulaceae, commonly known as Rudravanti is a erect, small, dwarf shrub, usually grows in sandy or muddy saline habitats. Cressa cretica is a plant that is referred to by the name that reflects the features of Sanjeevani. So this plant is commonly known as Sanjeevani in Sanskrit as it prolongs the life and prevents the onset of old age. It used as antibilious, antitubercular and expectorant. anthelmintic, stomachic, tonic and aphrodisiac purposes, enriches the blood and is useful in constipation, leprosy, asthma and urinary discharges, in the treatment of diabetes.

Keywords: Peptic ulcer, Herbal medicine, Cressa cretica, Pylorus ligation.