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Abstract

SYNTHESIS, CHEMICAL CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SOME NEW BENZIMIDAZOLE DERIVATIVES

Sangram U. Deshmukh*, Dr. B. Rajeeva, Balaji N. Thakare, M. J. Birajdar, Nandkishor B. Bavage

ABSTRACT

Substituted benzimidazole have received considerable attention during last decades as they are endowed with variety of biological activities and have wide range of therapeutic properties. The Mannich base derivatives of (1H-Benzimidazol-2-ylsulfanyl) acetic acid & 5- Methyl(1H-Benzimidazol-2-ylsulfanyl) acetic acid were synthesized and the structure of synthesized compound confirmed by spectroscopic techniques like 1H NMR, IR and mass spectrometry. All the synthesized compounds were screened in vitro for antibacterial and antifungal activity by paper disc diffusion method using Nutrient agar media against Bacillus subtilis, Bacillus pumilus, Escherichia coli and Pseudomonas aeruginosa, bacterial strain & potato dextrose agar medium against Aspergillus niger and Candida albicans. Cefrofloxacin were used as standard for antibacterial and Clotrimazole used as standard for antifungal activity respectively. The antimicrobial activity screening reveled that, the 3a1, 3a2 and 3a3 compounds were found to possess a significant activity against bacteria and 3a4 against fungi and rest of compounds are mild to moderate active in the conc. 100 μg/ml.

Keywords: Benzimidazole, Spectroscopy, Cefrofloxacin, bacillus subtilis, Clotrimazole, Disc diffusion.


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