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Abstract

KINETICS & STABILITY STUDIES OF CONTROLLED POROSITY OSMOTIC PUMP TABLET OF ATENOLOL

Ayesha Sultana* and D. Varun

ABSTRACT

The objective of the present study was to determine the curve fitting analysis and stability of controlled porosity osmotic pump tablet of Atenolol. The linearity of all the kinetic models was estimated. The optimized formulation follows zero order kinetics and the R2 for zero order was found to be 0.999 which is considered to be the best fit model. The drug release data was obtained, quantitatively correlated and interpreted by these kinetic mathematical models which are important for optimization of the formulations. These models helps to measure significant physical parameters such as drug diffusion coefficient and model fitting on experimental data. The optimized formulation was subjected to accelerated stability studies as per ICH guidelines. The temperature was maintained at 40 ± 2oC and relative humidity of 75 ± 5%. It was observed that no significant change in the drug release by dissolution during stability testing. This testing helps in selecting the best formulation from a series of formulations.

Keywords: Atenolol, Curve fitting, Optimization, Stability, Zero order.


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