Abstract

COMPARISON OF INTUBATING CONDITIONS AND HAEMODYNAMIC CHANGES USING ROCURONIUM AND VECURONIUM BROMIDE DURING ENDOTRACHEAL INTUBATION

Dr. Prithviraj Gomsale, Dr. Lokare S. S., Dr. Vaibhav Mahajan and *Dr. Deepak Phalgune

ABSTRACT

Background and Aims: Use of suxamethonium as muscle relaxant is associated with various side effects, some of which are inconvenient while others may be potentially harmful. Considering various side effects of succamethonium the present study was undertaken to compare the onset of action, intubating conditions and hemodynamic parameters using vecuronium and rocuronium for laryngoscopy. Methods: Sixty patients scheduled for different surgical speciality posted for various elective procedures under general anaesthesia were randomly divided into two groups. Thirty patients in Group A and Group B were given intubating dose of rocuronium 0.6mg/kg and vecuronium 0.1 mg/kg respectively Primary outcome measures were the onset of action whereas secondary outcome measure were intubating conditions and hemodynamic parameters using vecuronium and rocuronium for laryngoscopy. Comparison of quantitative and qualitative variables between groups was done using unpaired student’s “t” test and chi-square test respectively using statistical package for social sciences. Results: Onset of action of rocuronium [59.2(± 4.0) seconds] was significantly shorter than v ecuronium [136.6(± 6.6) seconds] with p value 0.001. The duration of action of vecuroniun [45.3(±3.1) minutes] of was slight longer than rocuronium [41.1(±4.4) minutes ]with p value 0.001. There was no statistically significant difference in intubating conditions. Conclusion: Rocuronium can be used as a muscle relaxant for laryngoscopy and intubation over v ecuronium.

Keywords: Rocuronium, v ecuronium, intubating conditions.