Abstract

A COMPARATIVE ESTIMATION OF CONTENT OF PARACETAMOL IN DIFFERENT FORMULATIONS USING UV-VISIBLE SPECTROPHOTOMETER

Pratiksha V. Rathi*

ABSTRACT

The quantitative determination of acetaminophen in Paracetamol tablets manufactured by five different manufacturer was done in this study. The result obtained by calculating Percent content of Paracetamol tablets containing 500mg acetaminophen using particular formula. The mean percentage determined in this analysis shows variation (minimum or maximum) than the claimed amount by the different manufacturers. The concentration of paracetamol of different brands was also investigated spectrophotometrically using UV-visible spectrophotometer and taken absorbance at wavelength 257 nm. The experimental conditions were optimized and Beers law was obeyed over the applicable concentration range. The technique was applied successfully for analysis of paracetamol in five different commercially available tablets. The overall study reveals that the current pharma market is flooded with various preparations. Therapeutic response of any formulation depends on its quality parameters.

Keywords: UV Spectrophotometer, Paracetamol Tablets, Comparative Estimation of Content of Paracetamol.