Abstract

FORMULATION AND INVITRO EVALUATION OF COLON TARGETED MICROSPHERES OF FENOPROFEN

K. Lakshmi Deepthi*, G. V. Radha and A. V. S. K. Bhavan 

ABSTRACT

Colon targeted drug delivery system is capable of protecting the drug in route to the colon i.e. drug release and absorption does not occur in stomach and small intestine, but only released and absorbed once it reaches the colon. A multiparticulate system combining pH sensitive property and biodegradability has been investigated to prepare and evaluate natural polymers with Sodium Alginate microspheres for colon targeting of Fenoprofen. Fenoprofen microspheres were prepared by Ionotropic Gelation Technique using different ratios of Fenoprofen and Sodium Alginate, along with polymers like karaya gum, gum kondagogu, okra gum, and Eudragit RL100. Fenoprofen microspheres were evaluated for percentage yield, particle size. Surface morphology, flow properties, drug content and entrapment efficiency and were found to be within the acceptable range. Invitro dissolution studies of the microspheres revealed that the formulation F15 containing karaya gum as a polymer shows maximum drug release at the end of 24hours, when compared with the other formulations. Drug release kinetics of the optimized formulation states that the formulation F15 follows zero order drug release with fickian diffusion mechanism.

Keywords: Colon targeted drug delivery with fickian diffusion mechanism.