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Abstract

FORMULATION AND EVALUATION OF DOMPERIDONE CANDY LOZENGES

B. Moulika Lakshmi*, Brahma K., G. Swathi, S. Sravani, P. Indira Rao and Dr. P. Shailaja

ABSTRACT

In spite of several dosage forms available in the market for effective action, the lozenges finds a special importance as they are the best dosage forms for formulating large dose medicaments. The anatomy of mouth and cheek favours easy and effective systemic absorption of drug and also better patient compliance especially for paediatrics and geriatrics due to their palatable taste imparted by the excipients. Domperidone is a selective serotonin receptor (5-HT3) antagonist and its lozenges are mainly used for the treatment of chemotherapy induced nausea and vomiting. In the present study lozenges dosage form is chosen due to their benefits of good patient compliance due to its taste, increased bioavailability, reduced gastric irritation, reduced first pass metabolism and increased onset of action when compared to its tablet dosage form which is in practice conventionally. The preparation process involves mixing of Domperidone with all excipients, used in the formulation in different ratios by using heat congealing technique in which sucrose and dextrose heated separately up to 600c fusioned together and reheated upto 1600c after which polymer HPMC K 100M, HPMC E5 and all other excipients are added and moulded. The lozenges were subjected to evaluation viz., weight variation test, hardness, friability, drug content and in vitro release studies.

Keywords: Domperidone, Heat congealing, lozenges, Chemotherapy induced nausea and vomiting.


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