Abstract

PHARMACOLOGICAL EVALUTION OF GYNOCARDIA ODORATA R. BROWN ROXB LEAVES EXRACTS FOR ITS ANTI-ULCER ACTIVITIES

Abhinav Kumar Chauhan*, B. M. Vrushabendra Swamy, R. K. Jat

ABSTRACT

Gastric ulcer is occurring in day today life due to excess use of NSAIDs, in stress, alcohol intake. For the treatment of gastric ulcer disease and peptic ulcer disease may chemical drugs are available in market such as Proton pump inhibitors, H2 Antihistaminic Drugs Anticholinergics The most serious side effect of proton pump inhibitors are Bacterial infections, Bone fractures, Damage to arteries, Dementia, Heart attack or heart failure, Kidney disease or injuries, Premature death, Stroke. The serious side effects H2 blocker are heart palpitations, galactorrhoea, gynecomastia, difficulty in breathing. From last 20 years people of world are move towards the herbal medicine because it will produce is very less toxic effect when we compare to chemical drugs. Loss on drying 0.554% w/w, Total Ash 3.96% w/w, Acid Soluble Ash 0.39% w/w, Water soluble Ash 1.30% w/w, Extractive values of Methanol 5.52% w/w, Water 9.042% w/w, Chloroform 2.30% w/w. The Phytochemical Tests shown Alkaloids, Carbohydrate, Glycosides, Phytosterols/Terpens Oils Protein, Tannins and Saponins. The TLC studies displayed the presence of compound such as, Flavonoid, Terpenoids and alkaloid with the significant Rf values. The pre-clinical pharmacological anti-ulcer impacts had seen by applying numerous extracts of Gynocardia odorata Roxb such as chloroform, methanol and aqueous on different gastric-ulcer models, are pylorus ligation, Stress induced, Aspirin induced, and Ethanol induce ulcers models. These test sample had administered thru oral route at a dose of 400mg/kg. Entirely extracts improved the ulcer healing of all gastric ulcers models (P< 0.05). But methanol extract had more significant when we equate with standard drug ranitidine (P< 0.001). In the pylorus ligation, stress induce ulcer, ethanol induces ulcer and aspirin induce ulcer showed remarkable anti-ulcer activities (P< 0.05). From this experiment and biochemical test result methanolic leaves extract of Gynocardia odorata Roxb had shown more significant ulcer healing activity.

Keywords: Gynocardia Odorata roxb, Ulcer index, anti-ulcer models, TLC and histopathology.