Abstract

PROTECTIVE ROLE OF COLOSTRUM AGAINST CCL4 INDUCED LIVER DAMAGE IN RATS

Alaa M. Abd El –Fattah, Samia M. EL-Dieb*, Fouad M. F. Elshaghabee

ABSTRACT

This study was carried out to evaluate the effect of cow and buffalo colostrum as a natural product on liver and kidney markers and antioxidant capcities after acute carbon tetrachloride (CCL4) exposure in male Sprague-Dawley rats. Our results showed that the activities of liver and kidney markers were significantly (P < 0.05) increased while the activities of antioxidant enzymes were significantly decreased in treated rats with CCL4. Oral administration of buffalo or cow colostrum for rats treated with CCL4 resulted in a significant decrease in the activities of liver and kidney markers and a significant increase in the activities of antioxidant enzymes were observed. No significant difference between rats administrated with cow or buffalo colostrum in their values of liver and kidney markers and antioxidant activities. Our results suggest that both types of colostrum could protect liver and kidney damage through enhancement the antioxidant capacities and improvement liver and kidney functions.

Keywords: Buffalo colostrum, Natural products, Hepatoprotective, Biochemical markers, Antioxidant capacity.