Abstract

STUDY ON FRACTURE HEALING ACTIVITY OF ETHNOMEDICINAL PLANTS IN WESTERN NEPAL

Sundar Adhikari, Tak Maya Gurung, Ajaya Koirala, Buddhi Raj Adhikari, Roshani Gurung, Suyog Basnet and Kalpana Parajuli*

ABSTRACT

Study on biological use of ethnomedicinal plant is of high interest in modern biological research. Researchers are interested in developing new sources of drug that can be from plant origin, which has been used locally by ethnic groups for treatment of disease state. In this study, effectiveness of the plants extract used locally in the treatment of bone fracture has been compared. Plant extract against calcium supplement was given to Swiss Albino rabbits and result was interpreted with x-ray analysis and measuring blood calcium and alkaline phosphate level. Data were expressed by their mean values ± standard deviation. X-ray observation showed that group fed with 100 mg/kg of formulation had the best healing property which was supported by serum calcium and alkaline phosphate level observation. Serum calcium level after 40 days of treatment was found 8.1 ± 0.59 mg/dl (test) compared to 10.06 ± 0.21 mg/dl (standard), whereas the serum alkaline phosphate level was 113 ± 6.56 IU/l (test) against 94.67 ± 8.5 IU/l (standard). This study showed that ethnomedicinal plant was comparatively effective in the treatment of fracture healing.

Keywords: Fracture healing, ethnomedicinal plant, serum calcium level, serum alkaline phosphate level.