Abstract

ANTIDIABETIC EFFECT OF METHANOLIC LEAF EXTRACT OF ARGYREIA CUNEATA WILLD. EX KER- AWL. (CONVOLVULACEAE)

S. Malathi*, V. Balasubramaniam, S. Jagathesh Kumar, R. Nantha Kumar and H. Abdul Kaffoor

ABSTRACT

The diabetes mellitus is major causes of characterize by derangement in fat,carbohydrate and protein metabolism, affecting people nearly 10% of the population. In the present study investigated methanolic leaf extract of Argyreia cuneata for 14 days on the functions of hyperinsulinemia, hyperglycemia, hyperlipidermic and serum hepatic marker enzymes were evaluated with streptozotocin (STZ) induced diabetic mellitus in mature male Wister rats. The results that a significant increase in the levels of urea, blood glucose, creatinine and glycosylated Hb and decrease in the level of plasma insulin in the diabetic control rats were observed. A reduce in the activities of serum protein, albumin and globulin in diabetic rats and these levels were increased in A. cuneatatreated groups III,IVand V. The marker enzymes SGOT, SGPT and ALP levels were significantly elevated in the STZ treated groups and compared to normal. The groups treated with A. cuneatamethanolic leaf extracts showed significantly decrease in the serum marker enzymes. The antidiabetic effect of A. cuneataextract was compared with a standard antidiabetic drug glibenclamide.

Keywords: Argyreia cuneata, antidiabetic,streptozotocin (STZ), methanolic leaf extracts.