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Abstract

ORODISPERSIBLE TABLET OF SALBUTAMOL BY USING NOVEL SUPERDISINTEGRANT

Gopal S. Gandhi*, Vaishali P. Wasnik, Kishor H. Lohiya, Rupali H. Tiple, Priya G. Shete

ABSTRACT

In the present investigation an attempt was made to develop immediate release solid dosage form of salbutamol sulphate. Salbutamol sulphate a selective β2 receptor agonist is widely used in initial therapy for chronic as well as acute asthma, an inflammatory disorder characterized by obstruction of air pathways and difficulty in breathing. The currently available conventional oral dosage forms are associated with lag time and delayed onset of action while aerosols and parenterals inspite of rapid onset of action strongly affect the patience compliance. Immediate release tablets are highly accepted fast growing drug delivery systems and thus, an attempt was made to improve the onset of action of drug. To achieve this goal, selective superdisintegrants croscarmellose sodium, crospovidone and Indion 414 in different concentrations (5 – 10 %w/w), were evaluated for their effect on the disintegration behavior of tablets, while microcrystalline cellulose and lactose were used as diluents. The tablets were prepared by direct compression method and were evaluated for various physicochemical properties, FTIR, in vitro disintegration and in vitro drug release studies.

Keywords: salbutamol sulphate, Beta blockers, Asthma, Superdisintegrants, Indion 414.


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