Abstract

ANTIMICROBIAL AND SPECTRAL STUDIES OF ZINC METAL COMPLEXES DERIVED FROM IMIDAZO [4, 5-F] [1, 10] – PHENANTHROLINE DERIVATIVE

Vithal M. Gugwad, Yogesh J. Yadav, Parashuram A. Jadhav and Dr. Anil A. Ghanwat*

ABSTRACT

The paper presents the synthesis of new zinc metal complexes derived from imidazo [4, 5- f] [1, 10] phenanthroline derivatives. All newly synthesized ligands & complexes were characterized by combination of elemental analysis, 1H-NMR, 13C-NMR and mass spectroscopy. Also, all the newly synthesized imidazo [4, 5-f] [1, 10] phenanthroline ligands and their zinc complexes were evaluated for their in vitro anti-microbial activity against the growth of bacteria and fungi to evaluate their antimicrobial potential. These studies revealed that the new complexes were found to have significant activity against the various bacterial and fungal organisms when compared with the standard antibiotics tetracycline and nystatin respectively and be more active than the parent ligand.

Keywords: Imidazo [4, 5-f] [1, 10] phenanthroline, Antibacterial activity, Metal complexes.