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Abstract

DESIGN, FORMULATION AND IN - VITRO EVALUATION OF OLANZAPINE MATRIX SUSTAINED RELEASE TABLETS USING NATURAL POLYMERS

P. SS. Prasanna Kumar*, G. Vijaya Kumar, B. Sravani, G. Lakshman Murthy, G.Raveendra Babu

ABSTRACT

Olanzapine is a thiaenobenzodiazepine derivative belongs to the class of second generation atypical anti-psychotic agents used for the treatment of schizophrenia, depressive episodes associated with bipolar disorder. The present study was to formulate and in-vitro evaluation of Olanzapine using natural polymers like Sodium alginate, Guar gum, Aegle Marmelos(Bael fruit) in the ratio of 1:2.5, 1:5, 1:7.5 by Direct Compression method. Each formulation was evaluated for various pre and post compression parameters such as flow property, Bulk density, Tapped density, Weight variation, Swelling index, Hardness, Friability, Assay, in-vitro dissolution. Among the 9 formulations, F8 formulation with 1:5 ratio of Olanzapine with Aegle marmelos showed the best dissolution rate studies. In-Vitro dissolution studies showed (99.93%) sustained release of drug up to 12 hours and the mechanism of drug release from the Sustained Release tablets was followed to be zero order kinetics with non-fickian diffusion. FTIR studies showed there was no interaction between the drug and polymers (or) excipients.

Keywords: Olanzapine, Anti psychotic, Guar gum, Sodium alginate, Aegle marmelos.


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