Abstract

PREPARATION AND CHARACTERIZATION OF FLOATING MICROSPHERES OF CIPROFLOXACIN HYDROCHLORIDE

Nethaji Ramalingam*, Mohamed Jassim A., Sunusha Praveen, Manikandan Palanivelu, N. Subramaniam Surendiran and Babu Ganesan

ABSTRACT

Ciprofloxacin hydrochloride (Hcl) is a fluoroquinolone antibiotic and effective against a gram positive and negative bacterial infections. It’s highly lipophilic and rapidly well absorbed after oral administration. The present study Ciprofloxacin Hcl floating microspheres were formulated with different concentration and blend of polymers like Ethyl cellulose, HPMC K4 M and HPMC K15M by non-aqueous solvent evaporation technique with an aim to controlled release and improve bioavailability. Depending upon the drug to polymer ratio, the percentage yield is found between 78.25% to 89.27% in all formulations. The entrapment efficiency of prepared floating microspheres was in the range of 72.67% to 89.27%. Microspheres showed a good specificity, spherical and uniform in shape with smooth surface and the mean particle size of microspheres significantly increase with increasing polymer concentration and it was range between 180.12±0.31 to 222.43±0.35 μm. Percentage buoyancy of floating microspheres was in the range of 69.87% to 85.36%. In-vitro drug release studies were performed in simulated gastric fluid which revealed that CP-III formulation was 98.53% drug release and CP-VII found 98.08% drug releases at the end of dissolution studies. Stability studies of selected floating microspheres showed good results. It could be also concluding that the all the formulations were shown satisfactory results and suitable for potential therapeutic uses.

Keywords: Ciprofloxacin Hcl, Floating Microspheres, In-vitro drug release, Stability studies.