WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

FORMULATION AND EVALUATION OF EZETIMIBE NANOSUSPENSIONS BY USING PRECIPITATION METHOD

Goutham Kuppili*, Prasanna Kumar Desu and Pasam Venkateswara Rao

ABSTRACT

In the present study, an attempt was made to prepare Nanosuspension of Ezetimibe is an anti-hyperlipidemic medication which is used to lower cholesterol levels. Nanosuspension containing the drug were prepared by precipitation method using combinations of polymers such as PVP K-25, Sodium lauryl sulphate (SLS), urea, poloxamer (188), and methanol. Estimation of Ezetimibe was carried out spectrophotometrically at 232nm. The Oral Nanosuspension were evaluated for various physical and biological parameters, drug content uniformity, particle size analysis, zeta potential, in-vitro drug release, short-term stability, drug- excipient interactions (FTIR). IR spectroscopic studies indicated that there are no drug-excipient interactions. The formulations F1 to F9 (containing PVP K-25, Urea, SLS, Poloxamer (188), and Methanol) used different ratio were found to be promising, of that formulation F9 containing Urea showed 99.43% release at the end of 25min & it follows zero order drug release kinetics. These formulations have displayed good Nanosuspension strength.

Keywords: Ezetimibe, Nanosuspension, PVP K-25, SLS, poloxamer (188), Urea and Methanol.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More