Abstract

ORAL IN-SITU FLOATING GELLING SYSTEM: REVIEW ON

Nilesh P. Salunkhe*, Dipak A. Patil, Sandip A. Tadavi, Sunil P. Pawar

ABSTRACT

In-situ gelling system explains about gels which are defined as intermediate state of matter consists of liquid and solid components. Hydrogels is defined as three dimensional structures which has capacity to retain bulk amount of water and also biological fluids to swell. Conventional oral dosage forms pose low bioavailability problems due to their rapid gastric transition from stomach, especially in case of drugs which are less soluble at alkaline pH of intestine. Similarly, drugs which produce their local action in stomach get rapidly emptied and do not get enough residence time in stomach. So, frequency of dose administration in such cases is increased. In-situ gels are type of hydrogels that are solution in form and undergo gelation in contact with body fluids or change in pH. Some of the polymers that are used in in-situ gelling system are guar gum, Xanthan gum, Sodium alginate, Sodium Benzoate, Sodium Citrate, Polyethylene glycon and Hydroxy Propyl methyl cellulose.

Keywords: In situ gel, Approches, Polymers, Evaluation.