Abstract

A REVIEW ON MICROSPHERES IN DRUG DELIVERY AS CARRIER

Hiranjith A.*, Ganesh N. S. and Vineeth Chandy.

ABSTRACT

Microspheres are the central novel drug delivery systems consisting of protein or synthetic polymers of free flowing powder having a particle size ranging from 1 to 1000μm. Microspheres show increase in bioavailability with a reduction in dosing frequency, thereby achieving better patient compliance and reduction in toxicity. Compared to the conventional dosage forms this drug delivery can improve its therapeutic efficacy. The purpose of the review is to focus on various type of microspheres like bioadhesive microspheres, floating microspheres, magnetic microspheres, radioactive microspheres, polymeric microspheres and the methods of formulation such as solvent evaporation, spray drying, quasi-emulsion solvent diffusion method, single emulsion technique, double emulsion technique, phase separation, and its wide range of applications when compared to other novel drug delivery systems.

Keywords: Microspheres, Novel Drug Delivery, Patient Compliance, Therapeutic Efficacy.