Abstract

ANTI-PROLIFERATIVE ACTIVITY OF SIDA CORDATA

Vikram E.N.T.* and N. Jayshree

ABSTRACT

Cancer therapy without any adverse effect is still a challenge in current scenario. Hence a wide search of remedies to treat cancer is being in progress. The aim of this study is to evaluate the anti-proliferative effect of the whole plant Sida cordata against KB cell lines. Ethyl acetate, ethanol and aqueous extracts of the whole plant Sida cordata at different concentrations (1000, 500, 250, 125, 62.5, 31.2, 15.6 and 7.8 μg/mL) were subjected to cytotoxic study. The anti-proliferative activity of various extracts were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The Ethanolic extract has shown good cytotoxic effect against KB cell line when compared with the ethyl acetate and aqueous extracts. The current study reveals that the whole plant Sida cordata can be used as a plant of interest to perform further anti-cancer studies at higher levels and it may fulfill various needs required in the current scenario of cancer treatment.

Keywords: Sida cordata, Phytoconstituents, MTT assay, KB cell lines, Anti-cancer activity.