Abstract

PHYTOCHEMISTRY AND ACTIVITY VASODILATOR OF SHEETS OF SPONDIAS MOMBIN L. (ANACARDIACEAE)

J. M. Tokoudagba*, Clement D. Gandonou, Alban Hougbeme, S. N. Gom, Cyril Auger, V. Schini-Kerth, A. Lobstein

ABSTRACT

The physiological study of the vasodilator activity of the ethanol-water extract of dried powdered leaves of the Spondias mombin L. showed vasorelaxant activity (EC50 of 90 mg / L) endothelium-dependent of NO and EDHF vasoactive factors. The liquid - liquid extraction of the extract of Spondias mombin gave polar fractions which are richer in total polyphenols than the apolar fractions. The study showed a good vasodilator activity for apolar fractions. The cyclohexane fraction is more active than dichloromethane fraction. The chemical study of the most active fraction of Spondias mombin L. (Anacardiaceae) allowed isolation of two molecules belonging to the family of terpenes: 3- [3-methyl-2- (1-methylhexyl) octyl ] phthalic acid and 2-hydroxy-6 - [(8'E, 11'e, 14'E) -2- hydroxydocosa-8 ', 11', 14'-trienyl] benzoic acid. These molecules are involved in vasodilating activity endothelium-dependent of the cyclohexane extract fraction of Spondias mombin.

Keywords: Spondias mombin, vasodilator activity, medicinal plants.