Abstract

BIOCHEMICAL STUDY ON THE REGENERATIVE EFFECT OF BEE VENOM ON EXPERIMENTALLY INDUCED DIABETES

Yakout A. El Senosi, Omayma, A. R. Abou Zaid, Afaf Desouky A. Elmaged and Mohamed A. M. Ali*

ABSTRACT

In the present study, the potential therapeutic effect of bee venom administration diabetic rats was evaluated. Thirty male albino rats were divided into three equal groups of 10 rats each. Group Ι:(Control group): received no drugs. Group II:(Diabetic rats group): rats received a single dose of Streptozotocin (STZ) (50- mg/kg-b.wt i.p). Group III:(Diabetic rats + bee venom treated group): rats are treated with + bee venom 0.5 mg /kg body weight /day, i.p) for 21 days after diabetes induction. Blood samples and pancreatic tissue were collected at the 22th day from the onset of bee venom administration. The obtained results showed that, STZ-induced diabetic rats exhibited a significant increase in serum glucose, triglycerides, total cholesterol, LDL-cholesterol, malondialdehyde (MDA), advanced glycation end products (AGEs) and glycated hemoglobin (HbA1c) with marked decrease in HDL-cholesterol, insulin levels, Catalase (CAT), glutathione peroxidase (GSH-px), superoxide dismutase (SOD). Treatment with bee venom was able to mitigate diabetic abnormalities through decreasing serum glucose, triacylglycerols, total cholesterol, LDL-cholesterol, malondialdehyde (MDA), advanced glycation end products (AGEs) and glycated hemoglobin (HbA1c) and increasing HDL-cholesterol, insulin levels, Catalase (CAT), glutathione peroxidease (GSH-px) and superoxide dismutase (SOD), These results suggest that bee venom are effective in increasing insulin sensitivity and secretion in diabetic rats and improving other biochemical blood parameters.

Keywords: Bee venom; STZ; Diabetes; lipid profil; Antioxidant enzymes; AGEs and HBA1c.