Abstract

FORMULATION AND EVALUATION OF CHITOSAN NANOPARTICLES OF THE HERBAL DRUG “MURVA”

N. Arulanandraj*, Dr. V. Gopal, S. Dhivya and Dr. G. Jayabalan

ABSTRACT

Aim: The aim of this study was to assess the potential of nanoparticles to improve the pharmacokinetics of Murva, with a primary goal of enhancing its bioavailability. Methods: Chitosan nanoparticles containing Murva (CNP1-CNP10) formulations were synthesized by ionic gelation technique, using a biodegradable polymer chitosan in varying ratios with tripolyphosphate anions (TPP). The prepared nanoparticles were evaluated for drug content, entrapment efficiency, particle size analysis, surface charge, drug release, surface morphology and release kinetics. Result: The chitosan nanoparticles showed drug content, drug entrapment efficiency and particle size in the ranges of 69.7-88.1%, 41.1-87.6% and 360-816nm respectively. The formulation CNP5 showed optimum drug release of 99.74% after 24 hrs. Conclusion: The developed Chitosan nanoparticulate system is a promising system for oral sustained administration of Murva and also enhances its bioavailability.

Keywords: Sustained release, Murva, nanoparticles, Chitosan.