Abstract

LEVOFLOXACIN ANTIBIOTIC TEST USED IN TASIKMALAYA CITY HEALTH CENTER AS QUALITY EVALUATION ON ANTIBIOTIC RESISTANCE CASE

Danni Ramdhani* and Resmi Mustarichie

ABSTRACT

Objective: Acute respiratory infections (ARIs) is an acute inflammation of the upper and lower respiratory tract caused by infection of microorganisms or bacteria, viruses, without or with inflammation of the lung parenchyma. The use of antibiotics is one way to overcome the disease ARIs. However, over time many occur resistant to the antibiotic. The purpose of this study was to determine the effectiveness of levofloxacin antibiotics to treat respiratory syndrome chemically that is by testing the levels of antibiotic drugs as a quality requirement of a drug. Methods: Drug sample obtained from health center of tasikmalaya city. The sample is a levofloxacin antibiotic used to treat the ARIs case. Tests carried out using UV-Visible spectrophotometer instrument, with validation parameters: linearity, precision, accuracy, Limit of Detection (LOD) and Limit of Quantification (LOQ). Result: The test results showed that the levels of levofloxacin antibiotics that are used to meet the requirements that exist in the Indonesian Pharmacopoeia grading 100,6%, and the validation parameters that meet the requirements, koefesisen correlation of 0.9969, accuracy 97.64%, precision 0.071%, LOD 15.88 and LOQ 52.95

Keywords: Levofloxacin, UV-Visible Spectrophotometer, Validation Parameters, Indonesia Pharmacopoeia.