Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL PROPERTIES OF NOVEL ISOXAZOLINE

Manorama Motegaonkar* and Suresh D. Dhage

ABSTRACT

Chalcones were synthesized by the condensation product of acetophenone in combination with aromatic aldehydes in presence of strong base. It was found that the synthesized chalcones were having prominent role in modern coordination chemistry. The chalcone synthesized by base catalyzed condensation of 3-acetyl-6-methyl-2Hpyran- 2,4-(3H) dione (DHA) with different aromatic aldehyde. These chalcones were used for synthesis of derivatives i.e. isoxazoline. The synthesized compounds were characterized by IR, 1HNMR and mass spectral analysis. The derivatives were further used for the estimation of its biological properties. It was found that the derivative possesses efficient antimicrobial properties. From the study it was found that the synthesized compounds are efficient for further research work.

Keywords: Dehydroacetic acid (DHA), Chalcone, 3-cinnamoyl-4-hydroxy-6-methyl-2- pyrones, IR, 1HNMR, Antibacterial activity, Antifungal activity, Isoxazoline.