Abstract

A RARE CASE ON METFORMIN INDUCED NEPHROTIC SYNDROME

Paul Joshisree K.*, Rajesh G. and Dr. Siddarama R.

ABSTRACT

Metformin is anti-diabetic drug used to treat type 2 diabetes patients. Proteinuria and oedema and nephrotic syndrome is occurs in association with wide variety of primary and systemic disease and also with drugs. Major drugs that can induce nephrotic syndrome and glomerular damage are gold, penicillamine, bucillamine and nonsteroidal anti-inflammatory drugs. Here we report a case of female patient of 68 years old who developed nephrotic syndrome after initiation of metformin. Whereas both De-challenge was done and ADR assessment scales like Naranjo scale and WHO scale shows possible ADR and it can be managed by stopping the medication. So, clinical pharmacist plays an important role in monitoring, detecting, and managing ADRs.

Keywords: Metformin, Nephrotic Syndrome, antidiabetic agent, adverse drug reaction.