Abstract

EVALUATION OF SERUM TESTOSTERONE, ESTRADIOL AND PSA LEVELS AMONG PRE- AND POST-MENOPAUSE BREAST CANCER FEMALE PATIENTS

Abdel-Aziz A.F., Abdelgawad M.R., Marzook E.A., Morsi R.M. and EL-Waseef A.M.

ABSTRACT

Breast cancer has emerged as the most common malignancy among females during the last few years. In Egypt breast cancer accounts for 37.7% of all new cancer cases among women. Early diagnosis is essential for disease management so research is underway to identify potential serological bio markers. Objective: To identify the diagnostic role of total prostate-specific antigen, CA 15-3, testosterone and estradiol levels in breast cancer in women pre and post-surgery. Also, studying the possible effect of diabetes mellitus in breast cancer female patients pre and post-menopause on levels of PSA and other parameters. Methods: The current study included 124 female patients with breast cancer and 37 healthy women serving as normal control groups. Serum CA 15-3, PSA, testosterone and estradiol levels were assayed before surgery and three week after surgery and in healthy controls. Results: In present study there was very highly significant increase in serum CA 15-3, PSA, estradiol and testosterone levels in all patients group compared to the control. On comparing Pre-surgery patients group to the Post-surgery patients group, it was found that serum CA 15-3, PSA and testosterone levels fall following breast surgery. Concerning diabetic patients, serum CA 15-3, PSA and testosterone levels were non-significantly changed compared to non-diabetic patients in all groups. As evident from the present data, diabetic female patients had lower estradiol level than non-diabetic female patients. Conclusions: The present study indicated a clinical significance of measurement of serum PSA in the diagnosis of women with breast cancer, and may be a useful marker for monitoring the response to treatment. CA15-3 is an important diagnostic, prognostic indicator. Estradiol and testosterone levels may play important roles in the development of breast cancer in older women. A single measurement of bioavailable estradiol and testosterone may be used to estimate a woman's risk for breast cancer. Based on these data we conclude that serum CA15-3 and PSA levels are useful tumor markers for breast cancer patient diagnosis or monitoring.

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