Abstract

STUDY ON PHYTOCHEMICALS, TOTAL PHENOLS, ANTIOXIDANT, ANTHELMINTIC ACTIVITY OF HOT WATER EXTRACTS OF CORIANDRUM SATIVUM SEEDS

Manju Madhavan* and Sheeja T Tharakan

ABSTRACT

Coriander sativum traditionally used in treatment of several diseases (inflammation, diabetes, hypertension, wounds, pain and fever).Its seeds are used for herbal drink preparation in Kerala and consumed as part of diet. The present study was carried out to investigate the phytochemical profile, total phenol content, antioxidant and anthelmintic activity of hot water extracts of seeds of Coriander sativum L. Phytochemical analysis showed the presence of flavonoids, tannins triterpenoids, saponins, steroids, alkaloids and carbohydrates. The total phenol content in 5 μg/ μl hot water extract is 36 μg/ μl phenol expressed as catechol equivalent. The radical scavenging potential showed dose dependent increase on increasing the concentration of coriander seed extracts 1-5 μg. IC50 value of Coriander sativum seeds was 3.78μg/μl. Anthelmintic activity also was dose dependant increase. At the highest concentration tested ie 75mg/ml it is almost comparable to the standard Albendazole.

Keywords: Coriander sativum, Phytochemical analysis, Anthelmintic activity, Antioxidant activity.