Abstract

NOVEL 4-THIAZOLIDINONE DERIVATIVES AS ANTI-MICROBIAL AND ANTIFUNGAL ACTIVITY

Sanskruti V. Maheshwari* and M. K. Thakor

ABSTRACT

The Fused Novel heterocyclic compounds (3a-h) namely N-(3,5diphenyl-3,3a-dihydrothiazolo[4,5-c]isoxazol-6(5H)-yl-2-(5-phenyl-2-thioxo-1,3,4-oxadiazol-3(2H)-yl propanamide were prepared and characterized. The compound N-(4-oxo-2-phenylthiazolidin-3-yl)-2-(5-phenyl-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)propanamide (1a-h) reacted with benzaldehyde gives Benzilidine derivatives (2a-h). Such compounds 2a-h on Condensation with hydroxyl amine gives title compounds i.e. 3a-h. All the compounds were screened for their antimicrobial activity.

Keywords: Oxadiazolo-thiazolidinones, Benzilidine 1,3,4- oxadiazol, antibacterial and antifungal activities.