Abstract

AN OVERVIEW OF POLYAMIDOAMINE DENDRIMERS: STRUCTURE, PHYSICAL PROPERTIES, AND BIOMEDICAL APPLICATIONS

Arka Sen Chaudhuri, Wenyan Li, Mengmeng Huo, Zhenghong Wu* and Xiaole Qi*

ABSTRACT

Polyamidoamine (PAMAM) dendrimers are the primary complete dendrimer family to be orchestrated, described and marketed. Dendrimers are hyper branched, monodispersed macromolecules with multivalent useful end bunches. Dendrimers have been investigated as nanocarrier for many drugs like anticancer, antiviral, antimalarial, antiprotozoal, anti-tubercular drugs. In spite of the fact that a number of various sorts of dendrimers containing distinctive center atoms, fanning monomers and surface practical gatherings, so they have been planned till date for medication conveyance applications, yet PAMAM dendrimers have been the most investigated dendrimers in such manner. In this review, we have focuses on relative information on PAMAM dendrimers especially significant to their properties, synthesis, lethality, biomedical applications and drug delivery characteristics.

Keywords: PAMAM dendrimers.