Abstract

COMPLICATIONS OF DIABETIC MOTHERS RELATED TO GLYCATED ALBUMIN AND HEMOGLOBIN LEVELS DURING PREGNANCY

Limna A.L., Kavitha P. Samy* and Sambathkumar R.

ABSTRACT

The prevalence of diabetes mellitus has been increasing globally and has turned into a universal burden. Pregnancy is a state which is described by developing insulin resistance that starts near mid pregnancy and develops through the third trimester and Gestational diabetes mellitus is the increased level of glucose in the blood or intolerance of blood glucose in the time of pregnancy. This may leads to the fetal compications such as Macrosomia, Hypoglycemia, Hyperbilirubinemia, Respiratory Distress Syndrome, Hypocalcemia, Polycythemia, Hypertrophic Cardiomyopathy, etc. The glycemic markers used commercially for detecting glycemic control includes HbA1c, glycated albumin, fructosamine and 1-5AG. Among that HbA1c is the most commonly used method. It is recognized that the demand for iron increases during the last trimester of pregnancy and that most mothers experience iron deficiency anemia; therefore, HbA1c may be increased relative to plasma glucose level during the last stage of pregnancy. Serum glycated albumin levels are unaffected by iron deficiency and thus may offer an adequate marker for monitoring glycemic control during pregnancy.

Keywords: Gestational diabetes mellitus, Glycemic markers, Glycated albumin.