Abstract

DESIGN AND EVALUATION OF NYSTATIN GEL BASED EMULSION FOR OROMUCOSAL FUNGAL INFECTION

Hayder Kadhim Drais*

ABSTRACT

Nystatin is a polyene antifungal that interferes with the permeability of the cell membrane of sensitive fungi by binding to sterols, chiefly ergosterol. Its main action is against Candida spp. It is practically insoluble in water, therefore, the objective of this research is a formulation and evaluation of nystatin gel based emulsion to be applied to the oromucosal surface to increase nystatin solubility that leads to improve local bioavailability. The formulation components were carbomer 940 and hydroxypropylmethyl cellulose K4 (HPMC K4) as gelling agent, aloe vera oil as a component of oily phase, tween 80 and span 80 as a surfactants. The aqueous and oleaginous phases of the emulsion were prepared and it was mixed with the prepared gel. Eight of nystatin gels based emulsion formulations (F1- F8) were prepared and subject to different gel based emulsion evaluation. The selected formula (F6) that has a higher release rate was encountered further investigation which is stability study. There is no important change was detected during stability studies. It can be concluded that the optimized formula (F6) was promising formula in protection of oromucosal from fungal infection.

Keywords: Nystatin, Gel based emulsion, Oromucosal fungal infection.