Abstract

CARBAZOLE DERIVATIVES IN CANCER TREATMENT- A REVIEW

Kanneti Naga Mounika*, Angirekula Naga Jyothi, Gollapalli Naga Raju, Rama Rao Nadendla

ABSTRACT

Cancer is genetic irregularity of immortal cells which aggravates various metabolic disorders that can be fatal and also untreatable. Every year it causes millions of death and therefore notoriously ranked on the second place in the category of deadly diseases. Present circumstances pose a serious threat to the current anticancer chemotherapy and are mainly governed by poor selectivity, high toxicity and increased incidences of resistance. Therefore there is prerequisite need of the new alternative scaffold which can become a lead molecule to eradicate the cancer anomalies. Carbazoles represent an important class of heterocycles. These have been reported to exhibit diverse biological activities such as antimicrobial, antitumor, antiepileptic, antihistaminic, antioxidant, anti-inflammatory, antidiarrhoeal, analgesic, neuroprotective and pancreatic lipase inhibition properties. The carbazole derivatives have gained the attention of researchers due to their therapeutic potential against neurological disorders and cell proliferation. Here in an attempt is made to review the medicinal importance of recently synthesized carbazole derivatives.

Keywords: Carbazoles, heterocycles, antidiarrhoeal, analgesic, neuroprotective.