FREE RADICAL SCAVENGING AND ANTI-DIABETIC ACTIVITY OF KIGELIA PINNATA
Dhriti V1., Chowdary P. V. V., Rahul J., Vishank G., Shivaji B. Bole*
ABSTRACT
Medicinal plant plays an essential role in the management of various
diseases. Kigelia pinnata commonly known as the Sausage tree, it is a
multipurpose medicinal plant with many characteristics and
considerable potentials. The plant has traditional uses which consist of
anticancer, antiulcer, anti-aging, antioxidant, and anti malarial, in the
treatment of genital infections, gynaecological disorders, renal
ailments, fainting etc., this work represents the recent profile of
applications of Kigelia pinnata as examined by different contemporary
scientific researches. In this study, the in vitro anti-oxidant activity,
anti-diabetic activity and phytochemical evaluation of four different
solvent extracts, from the leaves of Kigelia pinnata were determined. Phytochemical
screening of the extracts of the leaves showed the presence of flavanoids, alkaloids, etc. Antioxidant
activities of these extracts were evaluated through DPPH assay, reducing power
assay and phospho-molybednum assay. The anti-diabetic activities of these extracts were
determined by amylase inhibition assay. The anti oxidant and anti-diabetic activity of extracts
was found to be promising camparble with standard. IC50 was calculated for both antioxidant
and antidiabetic activity.The results obtained showed that the leaves of Kigelia pinnata has
anti-oxidant and anti-diabetic properties, which helps in providing a basis for the traditional
use of medicinal plant.
Keywords: Bignoniaceae, Kigelia pinnata, anticancer, anti-oxidant, anti-diabetic, DPPH.
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