DEVELOPMENT AND INVITRO EVALUATION OF GEL CONTAINIG ETHOSOMES ENTRAPPED WITH SULFASALAZINE
Sowjanya S*, Shivanand K, Divakar G, Tejaswi G, Venkatanagaraju E, Swetha M
ABSTRACT
Sulfasalazine drug is having half life of 5 to 7 h and used for the
treatment of rheumatoid arthritis. The oral use of Sulfasalazine is not
much recommended as it requires frequent administration. The
entrapment of drug in a vesicle has shown improved delivery of drug at
the targeted site and has also reduced the side effects thus, has shown
better patient compliance. Ethosomes are lipid vesicular carriers
containing high concentration of ethanol which provides better
penetration of drug into the skin. Ethosomes of Sulfasalazine were
prepared by hot method. The composition includes phospholipids (1-
3%), ethanol (20-40%), propylene glycol (10%) and distilled water up
to 100%. Liposomes of Sulfasalazine were also prepared by thin film
hydration technique. Selected formulations were subjected to sonication for reducing the
vesicle size. FT-IR study confirmed the purity of drug and revealed no interaction between
the drug and excipients. Ethosomes and liposomes were characterized for vesicle shape,
vesicle size, entrapment efficiency percentage, in vitro drug diffusion. Sonicated ethosomes
showed better results than unsonicated ethosomes. %CDR after 12 h for ethosomal, liposomal
are 92.3 ±0.323, 73.1 ±0.132 % and respectively. Ethosomal formulation (F6) was found
stable at 2-8°C and at room temperature during the storage of 2 months. Efficient delivery of
drug to deep skin stratum from ethosomal drug application found to be highly beneficial in
localizing the drug to desired site in the skin and reduced the side effects associated with
conventional treatments.
Keywords: Ethosomes; Sulfasalazine; Soya Phosphotidyl Choline.
[Download Article]
[Download Certifiate]